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SCIENTIFIC SUPPORT FOR EXOCELL PRODUCTS

Exocell products such as Albuwell M, Glycacor, Nephrat, Type IV Collagen, Nephrin, Podocalyxin and βig-h3 are supported by strong scientific research, including the following studies:


      Albuwell M
  • American Journal Physiology Renal Physiology 293:F1657-1665, 2007
    Interference with TGF-B signalling by Smad3-knockout in mice limits diabetic glomerulosclerosis without affecting albuminuria

  • American Journal Physiology Renal Physiology 292:F321-329, 2007
    Soluble betaglycan reduces renal damage progression in db/db mice

  • Nephron Experimental Nephrology 105:e45-e52, 2007
    Amelioration of established diabetic nephropathy by combined treatment with SMP-534 (antifibrotic agent) and losartan in db/db mice

  • American Journal Physiology Renal Physiology 290:F214-F222, 2006
    Impact of genetic background on nephropathy in diabetic mice

  • American Journal Physiology Heart Circ Physiology 290:H935-H940, 2006
    Angiotensin II hypertension is attenuated in interleukin-6 knockout mice

  • American Journal Physiology Renal Physiology 291:F1315-F1322, 2006
    Characterization of diabetic nephropathy in a transgenic model of hypoinsulinemic diabetes

  • American Journal Physiology Renal Physiology 290:F813-820, 2006
    SMP-534 ameliorates progression of glomerular fibrosis and urinary albumin in diabetic db/db mice

  • American Journal Physiology Renal Physiology 290:F828-F837, 2006
    Adenosine A2a receptor activation attenuates inflammation and injury in diabetic nephropathy

  • Nephron Experimental Nephrology 104:e23-e34, 2006
    Plasminogen activator inhibitor-1 deficiency has renal benefits but some adverse systemic consequences in diabetic mice

  • Journal American Society Nephrology 16:27-45, 2005
    Mouse models of diabetic nephropathy

  • American Society Nephrology 16:1289-1299, 2005
    Genome-wide scan in a novel IgA nephropathy model identifies a susceptibility locus on murine chromosome 10, in a region syntenic to human IGAN1 on chromosome 6q22-23

  • Diabetes 54:2628-2637, 2005
    Characterization of susceptibility of inbred mouse strains to diabetic nephropathy

  • American Journal Pathology 165:1243-1255, 2004
    Urinary excretion of fatty acid-binding protein reflects stress overload on the proximal tubules

  • Hypertension 43:364-369, 2004
    Role for thromboxanes receptors in angiotensin-II-induced hypertension

  • Journal Clinical Investigation 113:1390-1397, 2004
    Induction of B7-1 in podocytes is associated with nephritic syndrome

  • Diabetes 53:2101-2109, 2004
    Diminished loss of proteoglycans and lack of albuminuria in protein kinase C-?-deficient mice

  • Journal American Society Nephrology 14:1200-1211, 2003
    Focal and segmental glomerulosclerosis in mice with podocyte-specific expression of mutant ?-actinin-4

  • American Journal Pathology 162:1123-1137, 2003
    RAGE drives the development of glomerulosclerosis and implicates podocyte activation in the pathogenesis of diabetic nephropathy

  • Kidney International 64:1978-1985, 2003
    Gene expression profile in diabetic KK/Ta mice

  • Journal of Immunology 170:5658-5666, 2003
    CC chemokine ligand 5/RANTES chemokine antagonists aggravate glomerulonephritis despite reduction of glomerular leukocyte infiltration


      Glycacor
  • Atherosclerosis 202:162-168, 2009
    Glycation of LDL in non-diabetic people: Small dense LDL is preferentially glycated both in vivo and in vitro

  • Immunopharmacology Immunotoxicology 15:1-12, 2008
    Evaluation of serum biomarkers in nutritional disorders: Glycated apolipoprotein B, fasting serum glucose, fructosamine, stable and labile glycated hemoglobin in diabetic and non-diabetic subjects

  • Nutrition Metabolism & Cardiovascular Disease 17:6-12, 2007
    Glycated apolipoprotein B and myocardial infarction

  • Circulation 109:1750-1755, 2004
    Endothelial dysfunction and increased arterial intima-media thickness in children with type 1 diabetes

  • Diabetes Technology & Therapeutics 6:348-356, 2004
    Increased plasma glycated low-density lipoprotein concentrations in diabetes: A marker of atherogenic risk

  • Journal American Society Nephrology 10:332-341, 1999
    Non-insulin dependent diabetes mellitus and hypertriglyceridemia impair lipoprotein metabolism in chronic hemodialysis patients

  • Nephrology Dialysis Transplantation 12:1336-1343, 1997
    Uptake and metabolism of lipoproteins from patients with diabetes mellitus type II by glomerular epithelial cells


      Nephrat
  • Cell Biochemistry Biophysics 48:147-157, 2007
    Novel inhibitors of glycation and AGE formation

  • American Journal Physiology Regul Integr Comp Physiology 292:R769-R777, 2007
    17-estradiol supplementation reduces tubulointerstitial fibrosis by increasing MMP activity in the diabetic kidney

  • Diabetes 56:1842-1849, 2007
    Hyperglycemia is a major determinant of albumin permeability in diabetic microcirculation

  • American Journal Physiology Renal Physiology 290:F828-F837, 2006
    Adenosine A2a receptor activation attenuates inflammation and injury in diabetic nephropathy

  • Laboratory Investigation 86:357-368, 2006
    Expression of Smad1 is directly associated with mesangial matrix expansion in rat diabetic nephropathy

  • FASEB Journal 20:E150-E159, 2006
    Cellular and molecular mechanisms of tissue protection by lipophilic calcium channel blockers

  • American Journal Physiology Regul Integr Comp Physiology 290:R435-R441, 2006
    Endothelin antagonism prevents early EGFR transactivation but not increased matrix metalloproteinase activity in diabetes

  • Laboratory Investigation 86:927-939, 2006
    Angiotensin II-dependent Src and Smad1 signaling pathway is crucial for the development of diabetic nephropathy

  • American Journal Physiology Renal Physiology 289:F442-450, 2005
    Regulation of the renal thiazide-sensitive Na-Cl cotransporter, blood pressure, and natriuresis in obese Zucker rats treated with rosiglitazone

  • Diabetologia 46:1140-1152, 2003
    LR-90 a new advanced glycation endproduct inhibitor prevents progression of diabetic nephropathy in streptozotocin-diabetic rats

  • Journal American Society Nephrology 14:709-720, 2003
    Delayed treatment with lithospermate B attenuates experimental diabetic renal injury

  • Journal American Society Nephrology 14:3178-3187, 2003
    Role of 12-lipoxygenase in the stimulation of p38 mitogen-activated protein kinase and collagen ?5(IV) in experimental diabetic nephropathy and ion glucose-stimulated podocytes

  • American Journal Pathology 158:1733-1741, 2001
    A vitamin D analog ameliorates glomerular injury on rat glomerulonephritis

  • American Journal Society Nephrology 12:993-1000, 2001
    Antibodies against vascular endothelial growth factor improve early renal dysfunction in experimental diabetes


      Collagen Type IV
  • Diabetologia 51:198-207, 2008
    Monocyte chemoattractant protein-1 has prosclerotic effects both in a mouse model of experimental diabetes and in vitro in human mesangial cells

  • Nephron Experimental Nephrology 105:e45-e52, 2007
    Amelioration of established diabetic nephropathy by combined treatment with SMP-534 (antifibrotic agent) and losartan in db/db mice

  • American Journal Physiology Renal Physiol 292:F789-F795, 2007
    Inhibiting albumin glycation attenuates dysregulation of VEGFR-1 and collagen IV subchain production and the development of renal insufficiency

  • American Journal Physiology Renal Physiology 290:F813-820, 2006
    SMP-534 ameliorates progression of glomerular fibrosis and urinary albumin in diabetic db/db mice

  • Kidney International 68:1554-1561, 2005
    Evidence linking glycated albumin to altered glomerular nephrin and VEGF expression, proteinuria, and diabetic nephropathy

  • Kidney International 64:1632-1642, 2003
    Vitamin D3 up-regulated protein-1 regulates collagen expression in mesangial cells

  • Metabolism 50:1435-1440, 2001
    Increased urinary type IV collagen marks the development of glomerular [athology in diabetic db/db mice

  • Diabetes Care 24:914-918, 2001
    Increased collagen IV excretion in diabetes

  • Diabetes Care 24:1324-1327, 2001
    Serum type IV collagen in diabetic patients at risk for nephropathy

      Nephrin
  • PLoS One 7(5):e36041, 2012
    Dysregulated nephrin in diabetic nephropathy of type 2 diabetes: A cross sectional study

  • Am J Physiol Renal Physiol 302:F1084-F1089, 2012
    Increased urinary excretion of nephrin, podocalyxin and ?ig-h3 in women with preeclampsia

      Podocalyxin
  • Am J Physiol Renal Physiol 302:F1084-F1089, 2012
    Increased urinary excretion of nephrin, podocalyxin and βig-h3 in women with preeclampsia


      βig-h3
  • Am J Physiol Renal Physiol 302:F1084-F1089, 2012
    Increased urinary excretion of nephrin, podocalyxin and βig-h3 in women with preeclampsia




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